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Article

The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A.

Journal of virology - 1 Jul 1995

Satoh S, Tanji Y, Hijikata M, Kimura K, Shimotohno K

Abstract excerpt

Hepatitis C virus proteins are produced by proteolytic processing of the viral precursor polyprotein that is encoded in the largest open reading frame of the viral genome. Processing of the nonstructural viral polyprotein requires the viral serine-type proteinase present in nonstructural protein 3 (NS3). The cleavage of the junction between NS4B and NS5A is mediated by NS3 only when NS4A is present. NS4A is...

Topics

Base Sequence
Molecular Sequence Data
Mutation
Peptide Fragments
Serine Endopeptidases
Viral Nonstructural Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7769685
DOI: 10.1128/JVI.69.7.4255-4260.1995
PMCID: PMC189163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769685-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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