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Article

Analysis of NS3-mediated processing of the hepatitis C virus non-structural region in vitro.

The Journal of general virology - 1 Dec 1994

D'Souza E D, O'Sullivan E, Amphlett E M, Rowlands D J, Sangar D V, Clarke B E

Abstract excerpt

The protease activity of the hepatitis C virus (HCV) NS3 protein has been investigated using transient expression methods in mammalian cells, as well as in vitro transcription/translation systems. We confirmed that expression of the NS3-5 polyprotein in rabbit reticulocyte lysates results in efficient cis processing at the NS3/NS4 junction. However, processing at the other predicted sites of NS3-mediated cleavage...

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PMID: 7996139
DOI: 10.1099/0022-1317-75-12-3469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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