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Article

Suppression of tumorigenicity in human teratocarcinoma cell line PA-1 by introduction of chromosome 4.

Cancer research - 15 May 1994

McGowan-Jordan I J, Speevak M D, Blakey D, Chevrette M

Abstract excerpt

Teratocarcinomas are tumors that develop spontaneously in the gonads and usually contain a rapidly dividing, undifferentiated stem cell population. Immature ovarian teratocarcinomas are highly malignant with only 30-60% of patients surviving for 2 years after diagnosis. We have used microcell fusion to introduce individually tagged normal human chromosomes into the PA-1 human teratocarcinoma cell line....

Topics

Animals
Child
Chromosomes, Human, Pair 4
Female
Genes, Tumor Suppressor
Humans
Hybrid Cells
Karyotyping
Mice
Mice, Nude
Ovarian Neoplasms
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Teratocarcinoma

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 8168081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8168081-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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