Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.

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Article

Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.

American journal of human genetics - 1 Sept 1990

Giaccia A J, Denko N, MacLaren R, Mirman D, Waldren C, Hart I, Stamato T D

Abstract excerpt

XR-1 is a Chinese hamster ovary (CHO) cell mutant which is unusually sensitive to killing by gamma rays in the G1 portion of the cell cycle but has nearly normal resistance to gamma-ray damage in late S phase. The cell-cycle sensitivity correlates with the mutant's inability to repair DNA double-strand breaks (DSBs) produced by ionizing radiation and restriction enzymes. We have previously shown in somatic cell...

Topics

Animals
Bleomycin
Cell Cycle
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 5
Cricetinae
DNA
DNA Damage
DNA Repair
Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblasts

Gamma Rays

Genetic Complementation Test

Humans

Hybrid Cells

Karyotyping

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 1697445
PMCID: PMC1683886

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1697445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.PMID 1697445Read ↗

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