Article
Family-based linkage disequilibrium tests using general pedigrees.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Shugart Yin Yao, Chen Lina, Li Rui, Beaty Terri
Abstract excerpt
Linkage disequilibrium (LD) mapping has been established as a promising approach to identifying disease genes. The presence of a disease gene located near a marker locus may cause LD between the marker and the disease loci. In LD mapping, we assume that some of the affected individuals may have a common ancestor carrying the mutation and that mutation carriers are likely to share alleles at the markers loci close...
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