Model-free vs. model-based linkage analysis: a false dichotomy?

Abstract excerpt

The aim of this article is to dispel some misunderstandings concerning the concepts of model-free or nonparametric linkage analysis (usually meaning affecteds-only analysis) and model-based or parametric analysis (usually meaning classical lod scores) and the implications of these concepts for the linkage analysis of complex genetic diseases. I review basic principles and then briefly indicate actual research...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Gene Order
• Share to Genetic Linkage