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Article

Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2000

Kanagawa O, Xu G, Tevaarwerk A, Vaupel B A

Abstract excerpt

Nonobese diabetic (NOD) mice carrying a segment of chromosome flanking the disrupted IFN-gamma receptor gene from original 129 ES cells are resistant to development of diabetes. However, extended backcrossing of this mouse line to the NOD mouse resulted in a segregation of the IFN-gammaR-deficient genotype from the diabetes-resistant phenotype. These results indicate that the protection of NOD mice from the...

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Identifiers

PMID: 10725755
DOI: 10.4049/jimmunol.164.7.3919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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