Article
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.
Diabetes - 1 Dec 2000
Serreze D V, Post C M, Chapman H D, Johnson E A, Lu B, Rothman P B
Abstract excerpt
There have been two previous conflicting reports that the development of T-cell-mediated autoimmune diabetes (type 1 diabetes) was respectively unaffected or inhibited in NOD mice genetically deficient in the T-helper (Th) 1 cytokine interferon (IFN)-gamma or the alpha-chain subunit of its receptor. Our goal was to resolve this conundrum by congenically transferring, from a 129 donor strain to the NOD background,...
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