Article
Non-obese diabetic mice hemizygous at the T cell receptor alpha locus are susceptible to diabetes and sialitis.
European journal of immunology - 1 Apr 1996
Elliott J I, Altmann D M
Abstract excerpt
To test the hypothesis that T cells carrying two T cell receptor (TCR) alpha chains play a role in autoimmunity, we backcrossed the non-obese diabetic (NOD) strain with one carrying a TCR alpha gene disrupted by homologous recombination. Mice carrying one copy of the disrupted gene are incapable...
Topics
- Animals
- Autoimmune Diseases
- Base Sequence
- Blood Glucose
- Crosses, Genetic
- Diabetes Mellitus, Type 1
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Heterozygote
- Inflammation
- Islets of Langerhans
- Mice
- Mice, Inbred NOD
- Molecular Sequence Data
- Receptors, Antigen, T-Cell, alpha-beta
- Sialadenitis
- Specific Pathogen-Free Organisms