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Article

Non-obese diabetic mice hemizygous at the T cell receptor alpha locus are susceptible to diabetes and sialitis.

European journal of immunology - 1 Apr 1996

Elliott J I, Altmann D M

Abstract excerpt

To test the hypothesis that T cells carrying two T cell receptor (TCR) alpha chains play a role in autoimmunity, we backcrossed the non-obese diabetic (NOD) strain with one carrying a TCR alpha gene disrupted by homologous recombination. Mice carrying one copy of the disrupted gene are incapable of generating T cells carrying two cell surface TCR alpha chains. Our early results suggested that either dual TCR...

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Identifiers

PMID: 8625995
DOI: 10.1002/eji.1830260436

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