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Article

RAS is required for epidermal growth factor-stimulated arachidonic acid release in rat-1 fibroblasts.

Oncogene - 1 Dec 1993

Warner L C, Hack N, Egan S E, Goldberg H J, Weinberg R A, Skorecki K L

Abstract excerpt

Previous studies have provided suggestive evidence for an interaction between ras activation and signalling pathways involved in agonist-stimulated arachidonic acid release in a variety of cell systems. In order to clarify this interaction, we have measured epidermal growth factor (EGF)-stimulated arachidonic acid release in rat-1 fibroblasts transfected with the N-17 dominant negative mutation of ras. Cells...

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Source

Identifiers

PMID: 8247528

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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RAS is required for epidermal growth factor-stimulated arachidonic acid release in rat-1 fibroblasts.PMID 8247528Read ↗

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Rac mediates growth factor-induced arachidonic acid release.Semantic proximity Read ↗

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Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.Semantic proximity Read ↗

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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.Semantic proximity Read ↗

Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes.Semantic proximity Read ↗

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