A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling

Abstract excerpt

Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-enriched calcineurin interacting protein), that are expressed most abundantly in striated muscles and that form a physical complex with calcineurin A. MCIP1 is encoded by DSCR1, a gene located in the Down syndrome critical region. Expression of the MCIP family of proteins is up-regulated during muscle differentiation, and their...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Structural Anomalies and Repair
• Share to Peptidase Inhibition and Analysis
• Share to Signaling Pathways in Disease