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Article

METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2014

Huang Jian, Hsu Yi-Hsiang, Mo Chenglin, Abreu Eduardo, Kiel Douglas P, Bonewald Lynda F, Brotto Maxrco, Karasik David

Abstract excerpt

Sarcopenia and osteoporosis are important public health problems that occur concurrently. A bivariate genome-wide association study (GWAS) identified METTL21c as a suggestive pleiotropic gene for both bone and muscle. The METTL21 family of proteins methylates chaperones involved in the etiology of both myopathy and inclusion body myositis with Paget's disease. To validate these GWAS results, Mettl21c mRNA...

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Identifiers

PMID: 24677265
DOI: 10.1002/jbmr.2200
PMCID: PMC4074268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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