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Article

METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2014

Huang Jian, Hsu Yi-Hsiang, Mo Chenglin, Abreu Eduardo, Kiel Douglas P, Bonewald Lynda F, Brotto Maxrco, Karasik David

Abstract excerpt

Sarcopenia and osteoporosis are important public health problems that occur concurrently. A bivariate genome-wide association study (GWAS) identified METTL21c as a suggestive pleiotropic gene for both bone and muscle. The METTL21 family of proteins methylates chaperones involved in the etiology o...

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Identifiers

PMID: 24677265
DOI: 10.1002/jbmr.2200
PMCID: PMC4074268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24677265-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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