Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conserved family of calcineurin regulators.

Genes & development - 1 Jul 2000

Kingsbury T J, Cunningham K W

Abstract excerpt

The protein phosphatase calcineurin mediates many cellular responses to calcium signals. Using a genetic screen in yeast, we identified a new family of proteins conserved in fungi and animals that inhibit calcineurin function when overexpressed. Overexpression of the yeast protein Rcn1p or the human homologs DSCR1 or ZAKI-4 inhibited two independent functions of calcineurin in yeast: The activation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to Calcineurin Inhibitors
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to DNA, Recombinant

Share to Intracellular Signaling Peptides and Proteins

Share to Muscle Proteins

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 10887154
PMCID: PMC316734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved family of calcineurin regulators.PMID 10887154Read ↗

The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin.Semantic proximity Read ↗

Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.Semantic proximity Read ↗

Partial Inhibition of Calcineurin Activity by Rcn2 as a Potential Remedy for Vps13 Deficiency.Semantic proximity Read ↗

Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site.Semantic proximity Read ↗

The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p.Semantic proximity Read ↗

Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae.Semantic proximity Read ↗

Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast.Semantic proximity Read ↗

Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region.Semantic proximity Read ↗

Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae.Semantic proximity Read ↗

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathwaysSemantic proximity Read ↗

Vcx1-D1 (M383I), the Vcx1 mutant with a calcineurin-independent vacuolar Ca(2+)/H(+) exchanger activity, confers calcineurin-independent Mn(2+) tolerance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.