Article
Ccndbp1 is a new positive regulator of skeletal myogenesis.
Journal of cell science - 15 Jul 2016
Huang Yan, Chen Bohong, Ye Miaoman, Liang Puping, Zhangfang Yingnan, Huang Junjiu, Liu Mingyao, Songyang Zhou, Ma Wenbin
Abstract excerpt
Skeletal myogenesis is a multistep process in which basic helix-loop-helix (bHLH) transcription factors, such as MyoD (also known as MyoD1), bind to E-boxes and activate downstream genes. Ccndbp1 is a HLH protein that lacks a DNA-binding region, and its function in skeletal myogenesis is currently unknown. We generated Ccndbp1-null mice by using CRISPR-Cas9. Notably, in Ccndbp1-null mice, the cross sectional area...
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