Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation

Abstract excerpt

Muscle lim protein ( MLP ) has emerged as a critical regulator of striated muscle physiology and pathophysiology. Mutations in cysteine and glycine‐rich protein 3 ( CSRP 3 ), the gene encoding MLP , have been directly associated with human cardiomyopathies, whereas aberrant expression patterns are reported in human cardiac and skeletal muscle diseases. Increasing evidence suggests that MLP has an important role...

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