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Article

The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin.

Journal of molecular biology - 18 Apr 2003

Lee Jin Il, Dhakal Bijaya Kumar, Lee Jungsoo, Bandyopadhyay Jaya, Jeong Sang Young, Eom Soo Hyun, Kim Do Han, Ahnn Joohong

Abstract excerpt

A conserved family of calcineurin-regulating proteins whose members have been implicated in several disease models such as Down syndrome, Alzheimer's disease, and cardiac hypertrophy has been identified in several organisms including yeast, mice, and humans. We have characterized Caenorhabditis elegans rcn-1, which belongs to this family of calcineurin regulators, and shows approximately 40% identity with the...

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PMID: 12684004
DOI: 10.1016/s0022-2836(03)00237-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin.PMID 12684004Read ↗

A conserved family of calcineurin regulators.Semantic proximity Read ↗

Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans.Semantic proximity Read ↗

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathwaysSemantic proximity Read ↗

Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region.Semantic proximity Read ↗

Functional and phenotypic relevance of differentially expressed proteins in calcineurin mutants of Caenorhabditis elegans.Semantic proximity Read ↗

A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin SignalingSemantic proximity Read ↗

Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1Semantic proximity Read ↗

The neuronal and endocrine roles of RCAN 1 in health and diseaseSemantic proximity Read ↗

Systematic Functional Characterization of Human 21st Chromosome Orthologs in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Characterization of Caenorhabditis elegans Homologs of the Down Syndrome Candidate Gene DYRK1ASemantic proximity Read ↗

Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin in Caenorhabditis elegans.Semantic proximity Read ↗

Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans.Semantic proximity Read ↗

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