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Article

DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis.

Cancer research - 1 May 2003

Claij Nanna, van der Wal Anja, Dekker Marleen, Jansen Léon, te Riele Hein

Abstract excerpt

The primary role of the mismatch repair (MMR) system is the avoidance of mutations caused by replication and recombination errors. Furthermore, the lethality of methylating agents has been attributed to the processing of O(6)-methylguanine lesions in DNA by MMR. Loss of the MSH2 protein completely abolishes repair function and results in reduced cell killing by methylating agents and accelerated accumulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12727820

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis.PMID 12727820Read ↗

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Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.Semantic proximity Read ↗

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O 6 -methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivoSemantic proximity Read ↗

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