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Article

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.

The Journal of pathology - 1 Oct 2018

Champeris Tsaniras Spyridon, Villiou Maria, Giannou Anastassios D, Nikou Sofia, Petropoulos Michalis, Pateras Ioannis S, Tserou Paraskevi, Karousi Foteini, Lalioti Maria-Eleni, Gorgoulis Vassilis G, Patmanidi Alexandra L, Stathopoulos Georgios T, Bravou Vasiliki, Lygerou Zoi, Taraviras Stavros

Abstract excerpt

Geminin, a DNA replication licensing inhibitor, ensures faithful DNA replication in vertebrates. Several studies have shown that geminin depletion in vitro results in rereplication and DNA damage, whereas increased expression of geminin has been observed in human cancers. However, conditional inactivation of geminin during embryogenesis has not revealed any detectable DNA replication defects. In order to examine...

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PMID: 29952003
DOI: 10.1002/path.5128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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