Article
Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.
Nucleic acids research - 1 Jan 2006
Chao Elizabeth C, Lipkin Steven M
Abstract excerpt
A common feature of all the known cancer genetic syndromes is that they predispose only to selective types of malignancy. However, many of the genes mutated in these syndromes are ubiquitously expressed, and influence seemingly universal processes such as DNA repair or cell cycle control. The tissue specificity of cancers that arise from malfunction of these apparently universal traits remains a key puzzle in...
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