Article
Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus.
The European journal of neuroscience - 1 Jul 2003
von Gall Charlotte, Noton Elizabeth, Lee Choogon, Weaver David R
Abstract excerpt
Biological rhythms in mammals are driven by a central circadian clock located in the suprachiasmatic nucleus (SCN). At the molecular level the biological clock is based on the rhythmic expression of clock genes. Two basic helix-loop-helix (bHLH)/PAS-containing transcription factors, CLOCK and BMAL1 (MOP3), provide the basic drive to the system by activating transcription of negative regulators through E box...
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