Article
TP53 mutations and mdm2 protein overexpression in cholangiocarcinomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 2000
Della Torre G, Pasquini G, Pilotti S, Alasio L, Civelli E, Cozzi G, Milella M, Salvetti M, Pierotti M A, Severini A
Abstract excerpt
Tumor suppressor protein p53 is a positive regulator of MDM2 gene expression and the mdm2 protein can bind to p53, preventing the transactivation of p53 responsive genes, thus mimicking TP53 mutation. The authors looked for alterations that could affect, directly and indirectly, p53 function in 13 patients with extrahepatic cholangiocarcinoma. Molecular analysis by single strand conformation polymorphism and DNA...
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