Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MDM2-p53 pathway in hepatocellular carcinoma.

Cancer research - 15 Dec 2014

Meng Xuan, Franklin Derek A, Dong Jiahong, Zhang Yanping

Abstract excerpt

Abnormalities in the TP53 gene and overexpression of MDM2, a transcriptional target and negative regulator of p53, are commonly observed in cancers. The MDM2-p53 feedback loop plays an important role in tumor progression and thus, increased understanding of the pathway has the potential to improve clinical outcomes for cancer patients. Hepatocellular carcinoma (HCC) has emerged as one of the most commonly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation, Neoplastic
Share to Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Prognosis

Share to Proto-Oncogene Proteins c-mdm2

Share to Signal Transduction

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 25477334
DOI: 10.1158/0008-5472.CAN-14-1446
PMCID: PMC4504428

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MDM2-p53 pathway in hepatocellular carcinoma.PMID 25477334Read ↗

MDM2-p53 Interactions in Human Hepatocellular Carcinoma: What Is the Role of Nutlins and New Therapeutic Options?Semantic proximity Read ↗

The role of MDM2–p53 axis dysfunction in the hepatocellular carcinoma transformationSemantic proximity Read ↗

The MDM2-p53 pathway revisitedSemantic proximity Read ↗

Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?Semantic proximity Read ↗

The regulation of MDM2 oncogene and its impact on human cancers.Semantic proximity Read ↗

MDM2 in Tumor Biology and Cancer Therapy: A Review of Current Clinical TrialsSemantic proximity Read ↗

MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

Genetic alterations in hepatocellular carcinoma: An update.Semantic proximity Read ↗

Targeting the MDM2-p53 Interaction for Cancer TherapySemantic proximity Read ↗

Murine double minute 2 rs2279744 polymorphism and hepatocellular carcinoma risk in East Asians: a meta-analysis.Semantic proximity Read ↗

Involvement of DNA Damage Response Pathways in Hepatocellular CarcinomaSemantic proximity Read ↗

MDM2 antagonist can inhibit tumor growth in hepatocellular carcinoma with different types of p53 in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.