Article
Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma.
Journal of hepatology - 1 Aug 2001
Momoi H, Itoh T, Nozaki Y, Arima Y, Okabe H, Satoh S, Toda Y, Sakai E, Nakagawara K, Flemming P, Yamamoto M, Shimahara Y, Yamaoka Y, Fukumoto M
Abstract excerpt
BACKGROUND/AIMS: Intrahepatic cholangiocarcinoma (ICC) arises from intrahepatic bile duct epithelium and is the second most prevalent among primary liver cancers. The aim of this study was to clarify the mechanism of cholangiocarcinogenesis. METHODS: We studied the incidence of microsatellite instability (MSI) involving eight highly polymorphic microsatellite markers and alternations of the K-ras, p53 and mdm-2...
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