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Article

Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma.

International journal of oncology - 1 May 2006

Khan Shahid A, Taylor-Robinson Simon D, Carmichael Paul L, Habib Nagy, Lemoine Nicholas R, Thomas Howard C

Abstract excerpt

Cholangiocarcinoma development may be related to cholangiocyte DNA damage from genotoxic compounds in bile. We have previously shown that human biliary tissue is exposed to genotoxic agents, as evidenced by the presence of DNA adducts. Establishing the presence of a 'mutational signature' in tumour suppressor genes from tumour tissue provides a means of linking cause and effect in human cancer. Inactivation of...

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PMID: 16596244

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