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Article

The genetics of ivermectin resistance in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000

Dent J A, Smith M M, Vassilatis D K, Avery L

Abstract excerpt

The ability of organisms to evolve resistance threatens the effectiveness of every antibiotic drug. We show that in the nematode Caenorhabditis elegans, simultaneous mutation of three genes, avr-14, avr-15, and glc-1, encoding glutamate-gated chloride channel (GluCl) alpha-type subunits confers high-level resistance to the antiparasitic drug ivermectin. In contrast, mutating any two channel genes confers modest...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10716995
DOI: 10.1073/pnas.97.6.2674
PMCID: PMC15988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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