Article
A comparison of the effects of ivermectin and moxidectin on the nematode Caenorhabditis elegans.
Veterinary parasitology - 28 Oct 2009
Ardelli Bernadette F, Stitt Laurel E, Tompkins Jeffrey B, Prichard Roger K
Abstract excerpt
The avermectins and the milbemycins are structurally related classes of 16-membered macrocyclic lactones (ML) that have a broad spectrum of activity. Most studies on the mode of action of ML have used the avermectin, ivermectin (IVM). IVM activates glutamate-gated chloride channels that contain a...
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