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Article

Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.

Science (New York, N.Y.) - 3 Feb 2012

Ghosh Rajarshi, Andersen Erik C, Shapiro Joshua A, Gerke Justin P, Kruglyak Leonid

Abstract excerpt

Resistance of nematodes to anthelmintics such as avermectins has emerged as a major global health and agricultural problem, but genes conferring natural resistance to avermectins are unknown. We show that a naturally occurring four-amino-acid deletion in the ligand-binding domain of GLC-1, the alpha-subunit of a glutamate-gated chloride channel, confers resistance to avermectins in the model nematode...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22301316
DOI: 10.1126/science.1214318
PMCID: PMC3273849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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