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Article

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2000

Kane N S, Hirschberg B, Qian S, Hunt D, Thomas B, Brochu R, Ludmerer S W, Zheng Y, Smith M, Arena J P, Cohen C J, Schmatz D, Warmke J, Cully D F

Abstract excerpt

The fruit fly Drosophila melanogaster was used to examine the mode of action of the novel insecticide and acaricide nodulisporic acid. Flies resistant to nodulisporic acid were selected by stepwise increasing the dose of drug in the culture media. The resistant strain, glc(1), is at least 20-fold resistant to nodulisporic acid and 3-fold cross-resistant to the parasiticide ivermectin, and exhibited decreased...

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Identifiers

PMID: 11095718
DOI: 10.1073/pnas.240464697
PMCID: PMC17681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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