Mechanosensory Inputs Influence Caenorhabditis elegans Pharyngeal Activity via Ivermectin Sensitivity Genes

Abstract excerpt

Mechanical stimulation induces opposite behavioral responses in the adult and dauer pharynx. Tail tap of adults inhibits pharyngeal pumping via a pathway involving the innexin gene unc-7 and components of the glutamatergic pathway encoded by the genes avr-14 and avr-15. Tail tap of dauers stimulates pumping through a mechanism involving G alpha o and G alpha q. The nematocidal drug ivermectin is believed to kill...

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