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Article

Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.

The Journal of biological chemistry - 23 Dec 2011

Lynagh Timothy, Webb Timothy I, Dixon Christine L, Cromer Brett A, Lynch Joseph W

Abstract excerpt

Ivermectin is an anthelmintic drug that works by activating glutamate-gated chloride channel receptors (GluClRs) in nematode parasites. GluClRs belong to the Cys-loop receptor family that also includes glycine receptor (GlyR) chloride channels. GluClRs and A288G mutant GlyRs are both activated by low nanomolar ivermectin concentrations. The crystal structure of the Caenorhabditis elegans α GluClR complexed with...

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Identifiers

PMID: 22033924
DOI: 10.1074/jbc.M111.262634
PMCID: PMC3243547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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