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Article

Quantifying the fitness effects of resistance alleles with and without anthelmintic selection pressure using Caenorhabditis elegans.

PLoS pathogens - 1 May 2024

Shaver Amanda O, Miller Isabella R, Schaye Etta S, Moya Nicolas D, Collins J B, Wit Janneke, Blanco Alyssa H, Shao Fiona M, Andersen Elliot J, Khan Sharik A, Paredes Gracie, Andersen Erik C

Abstract excerpt

Albendazole (a benzimidazole) and ivermectin (a macrocyclic lactone) are the two most commonly co-administered anthelmintic drugs in mass-drug administration programs worldwide. Despite emerging resistance, we do not fully understand the mechanisms of resistance to these drugs nor the consequences of delivering them in combination. Albendazole resistance has primarily been attributed to variation in the drug...

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Identifiers

PMID: 38768235
DOI: 10.1371/journal.ppat.1012245
PMCID: PMC11142691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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