Article
Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
Molecular and cellular biology - 1 Apr 2000
Qiu H, Hu C, Anderson J, Björk G R, Sarkar S, Hopper A K, Hinnebusch A G
Abstract excerpt
Induction of GCN4 translation in amino acid-starved cells involves the inhibition of initiator tRNA(Met) binding to eukaryotic translation initiation factor 2 (eIF2) in response to eIF2 phosphorylation by protein kinase GCN2. It was shown previously that GCN4 translation could be induced independently of GCN2 by overexpressing a mutant tRNA(AAC)(Val) (tRNA(Val*)) or the RNA component of RNase MRP encoded by NME1....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.