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Article

The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.

Genes & development - 1 Dec 1998

Anderson J, Phan L, Cuesta R, Carlson B A, Pak M, Asano K, Björk G R, Tamame M, Hinnebusch A G

Abstract excerpt

Gcd10p and Gcd14p are essential proteins required for the initiation of protein synthesis and translational repression of GCN4 mRNA. The phenotypes of gcd10 mutants were suppressed by high-copy-number IMT genes, encoding initiator methionyl tRNA (tRNAiMet), or LHP1, encoding the yeast homolog of the human La autoantigen. The gcd10-504 mutation led to a reduction in steady-state levels of mature tRNAiMet,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9851972
DOI: 10.1101/gad.12.23.3650
PMCID: PMC317256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.PMID 9851972Read ↗

GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.Semantic proximity Read ↗

Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast speciesSemantic proximity Read ↗

Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.Semantic proximity Read ↗

Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.Semantic proximity Read ↗

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Degradation of hypomodified tRNA(iMet) in vivo involves RNA-dependent ATPase activity of the DExH helicase Mtr4p.Semantic proximity Read ↗

Fault-Tolerance Study on a Positive-Charged Cleft in 18S rRNA Methyltransferase DIMT1.Semantic proximity Read ↗

Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequencesSemantic proximity Read ↗

Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p.Semantic proximity Read ↗

Combined tRNA modification defects impair protein homeostasis and synthesis of the yeast prion protein Rnq1.Semantic proximity Read ↗

Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway.Semantic proximity Read ↗

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