Article
The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.
Genes & development - 1 Dec 1998
Anderson J, Phan L, Cuesta R, Carlson B A, Pak M, Asano K, Björk G R, Tamame M, Hinnebusch A G
Abstract excerpt
Gcd10p and Gcd14p are essential proteins required for the initiation of protein synthesis and translational repression of GCN4 mRNA. The phenotypes of gcd10 mutants were suppressed by high-copy-number IMT genes, encoding initiator methionyl tRNA (tRNAiMet), or LHP1, encoding the yeast homolog of...
Topics
- Adenosine
- Genes, Fungal
- Mutation
- Nuclear Proteins
- Peptide Chain Initiation, Translational
- RNA Processing, Post-Transcriptional
- RNA, Transfer, Met
- Saccharomyces cerevisiae
- Suppression, Genetic