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Article

A novel topology model of the human Na(+)/H(+) exchanger isoform 1.

The Journal of biological chemistry - 17 Mar 2000

Wakabayashi S, Pang T, Su X, Shigekawa M

Abstract excerpt

The membrane topology of the human Na(+)/H(+) exchanger isoform 1 (NHE1) was assessed by substituted cysteine accessibility analysis. Eighty-three cysteine residues were individually introduced into a functional cysteineless NHE1, and these mutants were expressed in the exchanger-deficient PS120 cells. The topological disposition of introduced cysteines was determined by labeling with a biotinylated maleimide in...

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Identifiers

PMID: 10713111
DOI: 10.1074/jbc.275.11.7942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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