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Article

Functional characterization of the transmembrane segment VII of the NHE1 isoform of the Na+/H+ exchanger.

Canadian journal of physiology and pharmacology - 1 Jan 2000

Ding Jie, Ng Raymond W P, Fliegel Larry

Abstract excerpt

The Na+/H+ exchanger isoform 1 is an integral membrane protein that regulates intracellular pH. It extrudes 1 intracellular H+ in exchange for 1 extracellular Na+. It has 2 large domains, an N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain. We characterized the cysteine accessibility of amino acids of the critical transmembrane segment TM VII. Residues Leu...

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Identifiers

PMID: 17612640
DOI: 10.1139/y06-081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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