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Article

Structural and functional analysis of transmembrane segment VI of the NHE1 isoform of the Na+/H+ exchanger.

The Journal of biological chemistry - 19 Nov 2010

Tzeng Jennifer, Lee Brian L, Sykes Brian D, Fliegel Larry

Abstract excerpt

The Na(+)/H(+) exchanger isoform 1 is a ubiquitously expressed integral membrane protein. It resides on the plasma membrane of cells and regulates intracellular pH in mammals by extruding an intracellular H(+) in exchange for one extracellular Na(+). We characterized structural and functional aspects of the transmembrane segment (TM) VI (residues 227-249) by using cysteine scanning mutagenesis and high resolution...

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Identifiers

PMID: 20843797
DOI: 10.1074/jbc.M110.161471
PMCID: PMC2978594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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