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Article

The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking.

Biochemistry - 3 May 2011

Nørholm Ann-Beth, Hendus-Altenburger Ruth, Bjerre Gabriel, Kjaergaard Magnus, Pedersen Stine F, Kragelund Birthe B

Abstract excerpt

Intrinsic disorder is important for protein regulation, yet its role in regulation of ion transport proteins is essentially uninvestigated. The ubiquitous plasma membrane carrier protein Na(+)/H(+) Exchanger isoform 1 (NHE1) plays pivotal roles in cellular pH and volume homeostasis, and its dysfunction is implicated in several clinically important diseases. This study shows, for the first time for any carrier...

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PMID: 21425832
DOI: 10.1021/bi1019989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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