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Article

Characterization of modeled inhibitory binding sites on isoform one of the Na+/H+ exchanger.

Biochimica et biophysica acta. Biomembranes - 1 Sept 2021

Li Xiuju, Kim Justin, Yang Jing, Dutta Debajyoti, Fliegel Larry

Abstract excerpt

Mammalian Na+/H+ exchanger isoform one (NHE1) is a plasma membrane protein responsible for pH regulation in mammalian cells. Excess activity of the protein promotes heart disease and is a trigger of metastasis in cancer. Inhibitors of the protein exist but problems in specificity have delayed their clinical application. Here we examined amino acids involved in two modeled inhibitor binding sites (A, B) in human...

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Identifiers

PMID: 33992631
DOI: 10.1016/j.bbamem.2021.183648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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