Article
Topology of NBCe1 protein transmembrane segment 1 and structural effect of proximal renal tubular acidosis (pRTA) S427L mutation.
The Journal of biological chemistry - 15 Mar 2013
Zhu Quansheng, Liu Weixin, Kao Liyo, Azimov Rustam, Newman Debra, Abuladze Natalia, Kurtz Ira
Abstract excerpt
In the kidney proximal tubule, NBCe1-A plays a critical role in absorbing HCO3(-) from cell to blood. NBCe1-A transmembrane segment 1 (TM1) is involved in forming part of the ion permeation pathway, and a missense mutation S427L in TM1 impairs ion transport, causing proximal renal tubular acidosis. In the present study, we examined the topology of NBCe1-A-TM1 in detail and its structural perturbation induced by...
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