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Article

Structural and functional analysis of transmembrane XI of the NHE1 isoform of the Na+/H+ exchanger.

The Journal of biological chemistry - 24 Apr 2009

Lee Brian L, Li Xiuju, Liu Yongsheng, Sykes Brian D, Fliegel Larry

Abstract excerpt

The Na(+)/H(+) exchanger isoform 1 is a ubiquitously expressed integral membrane protein that regulates intracellular pH in mammals by extruding an intracellular H(+) in exchange for one extracellular Na(+). We characterized structural and functional aspects of the critical transmembrane (TM) segment XI (residues 449-470) by using cysteine scanning mutagenesis and high resolution NMR. Each residue of TM XI was...

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Identifiers

PMID: 19176522
DOI: 10.1074/jbc.M809201200
PMCID: PMC2670159

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