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Article

Involvement of histidine residues in proton sensing of ROMK1 channel.

The Journal of biological chemistry - 17 Mar 2000

Chanchevalap S, Yang Z, Cui N, Qu Z, Zhu G, Liu C, Giwa L R, Abdulkadir L, Jiang C

Abstract excerpt

ROMK channels are inhibited by intracellular acidification. This pH sensitivity is related to several amino acid residues in the channel proteins such as Lys-61, Thr-51, and His-206 (in ROMK2). Unlike all other amino acids, histidine is titratable at pH 6-7 carrying a positive charge below pH 6. To test the hypothesis that certain histidine residues are engaged in CO(2) and pH sensing of ROMK1, we performed...

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Identifiers

PMID: 10713095
DOI: 10.1074/jbc.275.11.7811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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