Article
Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.
The Journal of physiology - 15 Oct 2002
Flagg Thomas P, Yoo Dana, Sciortino Christopher M, Tate Margaret, Romero Michael F, Welling Paul A
Abstract excerpt
The ROMK subtypes of inward-rectifier K(+) channels mediate potassium secretion and regulate NaCl reabsorption in the kidney. Loss-of-function mutations in this pH-sensitive K(+) channel cause Bartter's disease, a familial salt wasting nephropathy. One disease-causing mutation truncates the extreme COOH-terminus and induces a closed gating conformation. Here we identify a region within the deleted domain that...
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