Article
Identification and analysis of error types in high-throughput genotyping.
American journal of human genetics - 1 Sept 2000
Ewen K R, Bahlo M, Treloar S A, Levinson D F, Mowry B, Barlow J W, Foote S J
Abstract excerpt
Although it is clear that errors in genotyping data can lead to severe errors in linkage analysis, there is as yet no consensus strategy for identification of genotyping errors. Strategies include comparison of duplicate samples, independent calling of alleles, and Mendelian-inheritance-error checking. This study aimed to develop a better understanding of error types associated with microsatellite genotyping, as...
Topics
- Alleles
- DNA Mutational Analysis
- DNA Primers
- Female
- Genotype
- Humans
- Male
- Microsatellite Repeats
- Mutation
- Nuclear Family
- Polymerase Chain Reaction
- Reproducibility of Results