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Article

The trimmed-haplotype test for linkage disequilibrium.

American journal of human genetics - 1 Mar 2000

MacLean C J, Martin R B, Sham P C, Wang H, Straub R E, Kendler K S

Abstract excerpt

Single-marker linkage-disequilibrium (LD) methods cannot fully describe disequilibrium in an entire chromosomal region surrounding a disease allele. With the advent of myriad tightly linked microsatellite markers, we have an opportunity to extend LD analysis from single markers to multiple-marker haplotypes. Haplotype analysis has increased statistical power to disclose the presence of a disease locus in...

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Share to Chromosomes, Human
Share to Genetic Diseases, Inborn
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10712218
DOI: 10.1086/302796
PMCID: PMC1288142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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