Article
Linkage disequilibrium sharing and haplotype-tagged SNP portability between populations.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006
Huang Wei, He Yungang, Wang Haifeng, Wang Ying, Liu Yangfan, Wang Yi, Chu Xun, Wang Ying, Xu Liang, Shen Yayun, Xiong Xiaoyan, Li Hui, Wen Bo, Qian Ji, Yuan Wentao, Zhang Chenhui, Wang Yi, Jiang Hongquan, Zhao Guoping, Chen Zhu, Jin Li
Abstract excerpt
The discovery of the block-like structure of linkage disequilibrium (LD) in human populations holds the promise of delineating the etiology of common diseases. However, understanding the magnitude, mechanism, and utility of between-population LD sharing is critical for future genome-wide association studies. In this study, substantial LD sharing between six non-African populations was observed, although much less...
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