Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift.

doi:10.1007/s00439-003-0941-5

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Article

Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift.

Human genetics - 1 Jul 2003

Zhang Kun, Akey Joshua M, Wang Ning, Xiong Momiao, Chakraborty Ranajit, Jin Li

Abstract excerpt

There is considerable interest in identifying and characterizing block-like patterns of linkage disequilibrium (LD; haplotype blocks) in the human genome as these may facilitate the identification of complex disease genes via genome-wide association studies. Although recombination hot-spots have been suggested as the primary mechanism to explain the block-like pattern of LD, other forces, such as genetic drift,...

Topics

Computer Simulation
Crossing Over, Genetic
Evolution, Molecular
Genetic Drift
Genetic Variation
Haplotypes
Humans
Linkage Disequilibrium
Pattern Recognition, Automated
Polymorphism, Single Nucleotide
Recombination, Genetic

Source

Open in PubMed

Identifiers

PMID: 12677424
DOI: 10.1007/s00439-003-0941-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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