Article
The structure of haplotype blocks in the human genome.
Science (New York, N.Y.) - 21 Jun 2002
Gabriel Stacey B, Schaffner Stephen F, Nguyen Huy, Moore Jamie M, Roy Jessica, Blumenstiel Brendan, Higgins John, DeFelice Matthew, Lochner Amy, Faggart Maura, Liu-Cordero Shau Neen, Rotimi Charles, Adeyemo Adebowale, Cooper Richard, Ward Ryk, Lander Eric S, Daly Mark J, Altshuler David
Abstract excerpt
Haplotype-based methods offer a powerful approach to disease gene mapping, based on the association between causal mutations and the ancestral haplotypes on which they arose. As part of The SNP Consortium Allele Frequency Projects, we characterized haplotype patterns across 51 autosomal regions (spanning 13 megabases of the human genome) in samples from Africa, Europe, and Asia. We show that the human genome can...
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