Article
Characterization of multilocus linkage disequilibrium.
Genetic epidemiology - 1 Apr 2005
Rinaldo Alessandro, Bacanu Silviu-Alin, Devlin B, Sonpar Vibhor, Wasserman Larry, Roeder Kathryn
Abstract excerpt
Linkage disequilibrium (LD) in the human genome, often measured as pairwise correlation between adjacent markers, shows substantial spatial heterogeneity. Congruent with these results, studies have found that certain regions of the genome have far less haplotype diversity than expected if the alleles at multiple markers were independent, while other sets of adjacent markers behave almost independently. Regions...
Topics
- Algorithms
- Alleles
- Genetic Markers
- Genome, Human
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide