Role of evolutionary history on haplotype block structure in the human genome: implications for disease mapping.

doi:10.1016/j.gde.2003.10.010

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Article

Role of evolutionary history on haplotype block structure in the human genome: implications for disease mapping.

Current opinion in genetics & development - 1 Dec 2003

Tishkoff Sarah A, Verrelli Brian C

Abstract excerpt

With the completion of the first draft of the human genome sequencing project, a new challenge is to characterize patterns of linkage disequilibrium and haplotype structure across genomic regions to identify mutations associated with complex disease. Recent work shows considerable linkage disequilibrium heterogeneity, where genomic regions of extended haplotype blocks are punctuated by recombination hotspots. In...

Topics

Biological Evolution
Chromosome Mapping
DNA Mutational Analysis
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Recombination, Genetic

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Open in PubMed

Identifiers

PMID: 14638316
DOI: 10.1016/j.gde.2003.10.010

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