Article
Pedigree-Defined Haplotypes and Their Applications to Genetic Studies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Alper Chester A, Larsen Charles E
Abstract excerpt
A haplotype is a string of nucleotides or alleles at nearby loci on one chromosome, usually inherited as a unit. Within the major histocompatibility complex (MHC) region on human chromosome 6p, independent population studies of multiple families have identified conserved extended haplotypes (CEHs) that segregate as long stretches (≥1 megabase) of essentially identical DNA sequence at relatively high (≥0.5 %)...
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